The best gaming mouse with side buttons can put abilities, macros, push-to-talk, and everyday shortcuts within easy reach. The right model depends on how many controls you need, your preferred grip, and whether you want wired reliability or wireless freedom.
We compared these 10 options across button layouts, sensor performance, ergonomics, customization, and intended use so you can choose a mouse that fits your games and setup.
Best 10 Gaming Mouse with Side Buttons Picks for 2026
Versatile Control Pick
- 11 programmable buttons for flexible control
- 25,600 DPI HERO sensor
- Five adjustable weights
Best For: Right-handed gamers wanting a customizable wired mouse
MMO Macro Specialist
- 12 remappable side buttons
- 19 programmable buttons with five profiles
- Eight removable weights
Best For: MMO players needing maximum thumb-button access
Wireless Side-Button Pick
Razer Basilisk V3 X HyperSpeed
- Nine customizable controls
- HyperSpeed Wireless and Bluetooth
- Up to 285 hours of battery life
Best For: Gamers wanting wireless versatility and moderate button access
Budget MMO Button Value
- 12 angled side buttons
- 19 programmable buttons with five profiles
- Up to 16,400 DPI and adjustable weights
Best For: Wired MMO gaming with extensive customization
Reliable Essential
- Five programmable buttons
- 6,400 DPI optical sensor
- Right-handed wired design
Best For: Straightforward everyday gaming and creative work
MMO Command Center
- 12 programmable buttons
- Six side buttons for MMO commands
- Wireless or USB-C wired modes
Best For: MMO and MOBA players needing extensive controls
Customizable Control
- 11 programmable buttons
- HyperScroll tilt wheel
- 26,000 DPI optical sensor
Best For: Right-handed gamers wanting flexible controls and ergonomics
Maximum MMO Control
- 12 programmable side buttons and 18 total buttons
- Up to 12,400 DPI with software adjustment
- RGB profiles and removable weight tuning
Best For: MMO players who need extensive keybind customization
Adjustable Side-Button Layout
- 17 programmable buttons with 12 repositionable side buttons
- 18,000 DPI sensor with 1 DPI-step adjustment
- Contoured shape and durable rated switches
Best For: MMO and MOBA players who want customizable button placement
Everyday Programmable Value
- Eight programmable buttons for gaming and work
- Adjustable sensitivity up to 7,200 DPI
- Ergonomic shape with seven RGB modes
Best For: Users wanting basic side controls and macro support
Versatile Control Pick – Logitech G502 HERO
The Logitech G502 HERO is a practical choice if you want a gaming mouse with side buttons without moving to a specialized MMO layout. Its 11 programmable buttons, adjustable weights, and high-resolution sensor provide flexible control for PC gaming and everyday use.
Best For: Right-handed players who want customizable controls, adjustable balance, and a wired connection.
Pros:
- 11 programmable buttons, including multiple accessible side controls
- HERO sensor supports sensitivity up to 25,600 DPI without smoothing, filtering, or acceleration
- Five removable 3.6 g weights allow personalized balance
- Dual-mode hyper-fast scroll wheel and customizable LIGHTSYNC RGB lighting
Cons:
- Wired design does not offer wireless flexibility
- Right-handed shape limits use for left-handed players
The G502 HERO is a well-rounded option for gamers who want extra buttons for abilities, shortcuts, or macros while retaining a familiar general-purpose mouse layout.
MMO Macro Specialist – Redragon M901K
The Redragon M901K is built for shoppers specifically seeking a gaming mouse with side buttons in a high-button MMO layout. Its 12 remappable side buttons, 19 total programmable buttons, onboard profiles, and adjustable weights emphasize extensive command access.
Best For: MMO and MOBA players who need many thumb-accessible commands and profile-based customization.
Pros:
- 12 side buttons and 19 programmable buttons support extensive macro assignments
- Five memory profiles help save settings for different games or scenarios
- Adjustable DPI from 100 to 12,400 and polling rates from 125Hz to 1000Hz
- Eight removable 2.4 g weights allow balance tuning
Cons:
- The large number of buttons may take time to learn
- Wired connection limits cable-free setup
- Designed for right-handed use
Choose the M901K when button quantity is the priority. It offers more side controls than the other options here, making it especially suited to games with large action bars or complex command sets.
Wireless Side-Button Pick – Razer Basilisk V3 X HyperSpeed
The Razer Basilisk V3 X HyperSpeed is a strong option if you want a gaming mouse with side buttons and the convenience of wireless connectivity. It combines nine customizable controls with low-latency HyperSpeed Wireless, Bluetooth, and a long claimed battery life.
Best For: Right-handed gamers who want versatile wireless connectivity for gaming, work, and travel.
Pros:
- Nine programmable controls support macros, shortcuts, and custom commands
- HyperSpeed Wireless and Bluetooth provide two connection modes
- Up to 285 hours on HyperSpeed Wireless or 535 hours over Bluetooth
- 18,000 DPI optical sensor, onboard profile storage, and Chroma RGB
Cons:
- Uses a single AA battery rather than a rechargeable internal battery
- Offers fewer total buttons than the MMO-focused mice
- Right-handed design is not suited to left-handed users
The Basilisk V3 X is the most flexible pick for mixed use. It gives you useful side controls without the dense 12-button panel of an MMO mouse, while its dual wireless modes make it easier to move between devices.
Budget MMO Button Value – UtechSmart Venus Pro
The UtechSmart Venus Pro targets players who want a gaming mouse with side buttons and a full MMO-style control layout. It provides 12 thumb buttons, 19 programmable buttons, five profiles, adjustable weights, and a wired design with a braided cable.
Best For: Right-handed MMO gamers seeking extensive programmable controls and adjustable balance at a wired setup.
Pros:
- 12 angled side buttons are designed for quick thumb access
- 19 programmable buttons and five custom profiles support varied game setups
- Adjustable sensitivity from 200 to 16,400 DPI
- Eight included 2.4 g weights allow customized balance
Cons:
- Windows-only operating-system support is listed in the supplied details
- Wired design may be less convenient than a wireless mouse
- The many buttons can feel overwhelming for simpler games
The Venus Pro makes the most sense for MMO players who value a large number of accessible commands, profile switching, and weight adjustment more than a streamlined design or wireless freedom.
Reliable Essential – Razer DeathAdder Essential
The Razer DeathAdder Essential is a straightforward wired gaming mouse with side buttons for players who want dependable control without a complex feature set. Its right-handed ergonomic shape, five programmable buttons, and 6,400 DPI optical sensor suit everyday PC gaming and general creative work.
Best For: Right-handed gamers seeking a simple, lightweight wired mouse with essential programmable controls.
Pros:
- Five programmable buttons support remapping and macro assignments.
- 6,400 DPI optical sensor offers adjustable sensitivity.
- Mechanical switches are rated for up to 10 million clicks.
- Ridged rubberized scroll wheel provides controlled, tactile scrolling.
Cons:
- Wired connectivity limits cable-free flexibility.
- Its five-button layout provides fewer controls than MMO-focused alternatives.
- Designed for right-handed use.
The DeathAdder Essential keeps the focus on familiar ergonomics and practical controls. It is a sensible pick if you need a reliable gaming mouse with side buttons rather than extensive lighting, wireless connectivity, or a large macro layout.
MMO Command Center – ASUS ROG Spatha X
The ASUS ROG Spatha X is built for players who need a gaming mouse with side buttons and extensive command access. It combines six strategically positioned side buttons with 12 programmable controls, dual-mode wireless or USB-C connectivity, and a high-resolution 19,000 DPI sensor.
Best For: MMO and MOBA players who want numerous programmable inputs, wireless flexibility, and a large ergonomic shape.
Pros:
- Twelve programmable buttons include six side buttons for complex game commands.
- Supports low-latency 2.4GHz wireless and USB-C wired modes.
- 19,000 DPI sensor and 1,000 Hz polling rate support precise tracking.
- Rechargeable battery provides up to 67 hours with RGB lighting off.
Cons:
- Its large shape may not suit players who prefer compact mice.
- Extensive controls and customization may be unnecessary for simpler games.
- Designed for right-handed use.
The Spatha X is the most feature-heavy option here for games that demand frequent ability, item, or macro inputs. Its hot-swappable switches, charging dock, and dual-mode connection add flexibility, though the larger MMO-oriented design is best matched with users who will take advantage of its many buttons.
Customizable Control – Razer Basilisk V3
The Razer Basilisk V3 is a versatile wired gaming mouse with side buttons, a thumb rest, and 11 programmable buttons for assigning macros or secondary functions. It also adds a customizable RGB system, a tilt-enabled HyperScroll wheel, and a 26,000 DPI optical sensor.
Best For: Right-handed PC gamers who want an ergonomic mouse with broad button customization and adjustable scroll behavior.
Pros:
- Eleven programmable buttons support macros and functions such as push-to-talk or ping.
- Ergonomic shape and thumb rest support a comfortable right-handed grip.
- HyperScroll tilt wheel switches between free-spinning and tactile modes.
- 26,000 DPI optical sensor and Gen 2 optical switches provide precise, responsive control.
Cons:
- Wired connectivity is less flexible than a wireless design.
- Its numerous features may be more than casual players need.
- Designed for right-handed use.
The Basilisk V3 balances accessible ergonomics with a generous set of programmable controls. Choose it if you want a gaming mouse with side buttons for both in-game commands and desktop shortcuts, plus a scroll wheel and lighting system that can be customized through Razer software.
Maximum MMO Control – Redragon M908
The Redragon M908 is a gaming mouse with side buttons designed for players who want many commands close at hand. Its 12 programmable side buttons, 18 total buttons, adjustable DPI, RGB lighting, and weight-tuning system make it especially suited to MMO keybinds and customizable PC setups.
Best For: MMO players who want extensive remapping options and adjustable weight.
Pros:
- 12 programmable side buttons and 18 total buttons support complex keybinds.
- Adjustable sensitivity from 200 to 12,400 DPI through software.
- Includes five memory profiles, RGB lighting, and eight removable weights.
- Uses a Pixart PAW3327 optical sensor with a 1000 Hz polling rate.
Cons:
- Its 175 g weight may feel heavy compared with lighter gaming mice.
- The extensive button layout is more specialized than a standard mouse.
- Programmable features require compatible software; Mac use is listed as normal use only.
The M908 is a feature-heavy choice for MMO-focused gamers who value abundant controls and customization over a minimalist design. Its right-handed shape, weight kit, and profile storage help tailor the mouse to different games.
Adjustable Side-Button Layout – Corsair Scimitar RGB Elite
The Corsair Scimitar RGB Elite is a gaming mouse with side buttons built around MMO and MOBA controls. Its 12-button Key Slider system lets you reposition the side cluster to better match your grip, while the 18,000 DPI sensor provides fine tracking adjustment.
Best For: MMO and MOBA players who want a repositionable side-button panel and durable construction.
Pros:
- Offers 17 fully programmable buttons, including 12 repositionable side buttons.
- Key Slider Control System helps fit the side buttons to different grips.
- Native 18,000 DPI PixArt PMW3391 sensor adjusts in 1 DPI steps.
- Includes 50-million-click-rated Omron switches and a braided cable.
Cons:
- The 17-button layout may be excessive for users who prefer simple controls.
- It is a right-handed mouse, limiting suitability for left-handed users.
- Its larger, contoured design may not suit every hand or grip preference.
The Scimitar RGB Elite stands out when side-button positioning matters as much as button count. It is a strong fit for players willing to configure the mouse around their hand and game-specific macros.
Everyday Programmable Value – Redragon M602
The Redragon M602 is a more straightforward gaming mouse with side buttons for players who want useful remapping without an MMO-style button grid. It combines adjustable DPI up to 7,200, software-based macro editing, an ergonomic right-handed shape, and seven RGB lighting modes.
Best For: Budget-conscious gamers and everyday users who want a comfortable programmable mouse with basic side controls.
Pros:
- Eight total buttons provide programmable controls without an overly dense layout.
- Adjustable sensitivity reaches up to 7,200 DPI.
- Software supports button remapping, macro editing, lighting, and speed adjustments.
- Ergonomic shape is designed to accommodate different hand sizes and grips.
Cons:
- It has fewer buttons than dedicated MMO mice such as the M908 or Scimitar.
- Programmable functions require downloading the Redragon software.
- Its listed 2015 launch makes it an older design than the other options here.
The M602 is a sensible pick when you need a few side commands, adjustable sensitivity, and software customization rather than a full MMO control panel. Its simpler layout may also be easier to learn for general gaming and work.
How We Picked the Best Gaming Mouse with Side Buttons
We focused on the features that matter most when choosing a Gaming Mouse with Side Buttons: button count and placement, sensor specifications, connection type, software support, ergonomics, and overall versatility. The lineup includes simple two-button designs for FPS and general use, as well as MMO-focused mice with extensive macro controls.
We also considered whether each mouse is best suited to right-handed users, the grip styles it can accommodate, and how easily its buttons can be remapped. DPI figures are only one part of performance, so they were considered alongside tracking capability, control layout, and practical usability.
Quick Comparison
| Best For | Recommended Type | What to Look For |
|---|---|---|
| MMO and extensive macros | 12- or 19-button mouse | Comfortable thumb grid, onboard profiles, configurable software |
| FPS and general gaming | Two- or three-side-button mouse | Lightweight shape, reliable sensor, easy-to-reach controls |
| Wireless setups | Wireless ergonomic mouse | Stable connection, battery life, charging options |
| Budget customization | Wired remappable mouse | Useful software, adjustable DPI, durable cable and switches |
Key Buying Factors for a Gaming Mouse with Side Buttons
Button Layout and Count
More buttons are not automatically better. Two side buttons are usually enough for shooters, action games, browsing, and push-to-talk. MMO players may benefit from a thumb grid or a larger bank of programmable controls, but the layout should let you identify buttons without looking.
Shape, Grip, and Comfort
Check the mouse dimensions and intended hand orientation before buying. A tall ergonomic design can support palm grips, while a lower or narrower shape may suit claw or fingertip users. Extra side buttons should remain reachable without forcing your thumb into an awkward position.
Sensor and Adjustability
Look for consistent tracking, adjustable sensitivity, and a polling rate that suits your system. Very high DPI ratings are rarely essential; a stable sensor with precise low- and mid-sensitivity control is generally more useful.
Wired Versus Wireless
Wired mice avoid charging and typically offer straightforward plug-and-play use. Wireless models reduce cable drag and can make a desk feel cleaner, but check battery life, charging behavior, connection stability, and whether the mouse supports use while charging.
Software and Compatibility
Remapping, macros, lighting, and profile storage depend on the manufacturer’s software. Confirm compatibility with your operating system and favorite games, especially if you need complex macros or want settings available across multiple computers.
Who Should Buy Which Gaming Mouse with Side Buttons?
Choose a high-button MMO model if you play games that demand frequent ability access or use many application shortcuts. A conventional ergonomic mouse with a few side controls is a better fit for FPS players, mixed gaming, and everyday productivity. Choose wireless if freedom from cable drag matters most, and choose wired if you prefer continuous availability and simple setup. Finally, prioritize hand comfort and button reach over headline DPI or lighting features: a mouse you can control comfortably for hours will outperform one with specifications you rarely use.